A list of full-text open-access Space Science publications

Search An Article 14-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification? 37-day microgravity exposure in 16-week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites., A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster A Compact Imaging Platform for Conducting C. elegans Phenotypic Assays on Earth and in Spaceflight. A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing. A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection. A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: Host extracellular to systemic effects of SARS-CoV-2 infection, A conditional mutation in SCD1 reveals linkage between PIN protein trafficking, auxin transport, gravitropism, and lateral root initiation. A Member of the CONSTANS-Like Protein Family is a Putative Regulator of ROS Homeostasis and Spaceflight Physiological Adaptation A method for preparing spaceflight RNAlater-fixed Arabidopsis thaliana (Brassicaceae) tissue for scanning electron microscopy. A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity. A New Era for Space Life Science: International Standards for Space Omics Processing A new role of NAP1L1 in megakaryocytes and human platelets A novel blue-light phototropic response is revealed in roots of Arabidopsis thaliana in microgravity A novel phototropic response to red light is revealed in microgravity. A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells A region of UNC-89 (obscurin) lying between two protein kinase domains is a highly elastic spring required for proper sarcomere organization A ROS-assisted calcium wave dependent on AtRBOHD and TPC1 propagates the systemic response to salt stress in Arabidopsis roots A Tissue Retrieval and Postharvest Processing Regimen for Rodent Reproductive Tissues Compatible with Long-Term Storage on the International Space Station and Postflight Biospecimen Sharing Program Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle Acceleration profiles and processing methods for parabolic flight. Acute exposure to high dose gamma-radiation results in transient activation of bone lining cells Adaptation to full weight-bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery, Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis, Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis., Adaptive Changes in the Vestibular System of Land Snail to a 30-Day Spaceflight and Readaptation on Return to Earth Advances in Space Microbiology, Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise Aging and estrogen status: A possible endothelium-dependent vascular coupling mechanism in bone remodeling Aging and putative frailty biomarkers are altered by spaceflight Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environmen Altered disc compression in children with idiopathic low back pain: an upright magnetic resonance imaging backpack stud Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis, An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity, An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells. Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble., ANN1 and ANN2 Function in Post-Phloem Sugar Transport in Root Tips to Affect Primary Root Growth Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model Apyrase inhibitors enhance the ability of diverse fungicides to inhibit the growth of different plant-pathogenic fung ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight Articular cartilage and sternal fibrocartilage respond differently to extended microgravity. Artificial gravity attenuates the transcriptomic response to spaceflight in the optic nerve and retina, Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster., Asparagine biosynthesis as a mechanism of increased host lethality induced by Serratia marcescens in simulated microgravity environments Assessing the risk of transfer of microorganisms at the International Space Station due to cargo delivery by commercial resupply vehicles Astronaut omics and the impact of space on the human body at scale, AtRabD2b and AtRabD2c have overlapping functions in pollen development and pollen tube growth. Autophagy and its consequences for platelet biology, Auxin: Shape matters Back pain in space and post-flight spine injury: Mechanisms and countermeasure developmen Basal signaling regulates plant growth and development Beyond low-Earth orbit: Characterizing immune and microRNA differentials following simulated deep spaceflight conditions in mice. Biocontrol in built environments to reduce pathogen exposure and infection risk., Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces., Biological horizons: pioneering open science in the cosmos, Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: Proof of concept., Bisphosphonates attenuate age-related muscle decline in Caenorhabditis elegans., Blocking SARS-CoV-2 Delta variant (B.1.617.2) spike protein receptor-binding domain binding with the ACE2 receptor of the host cell and inhibiting virus infections using human host defense peptide-conjugated graphene quantum dots. Bone hemodynamic responses to changes in external pressure. Bone Marrow Adipose Tissue Deficiency Increases Disuse-Induced Bone Loss in Male Mice Bone Marrow Adipose Tissue Is Not Required for Reconstitution of the Immune System Following Irradiation in Male Mice, Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice. Bone remodeling is regulated by inner ear vestibular signals Bone shaft bending strength index is unaffected by exercise and unloading in mice Brassinazole resistant 1 (BZR1)-dependent brassinosteroid signalling pathway leads to ectopic activation of quiescent cell division and suppresses columella stem cell differentiation Brassinosteroids inhibit autotropic root straightening by modifying filamentous-actin organization and dynamics. Burn injury-associated MHCII(+) immune cell accumulation around lymphatic vessels of the mesentery and increased lymphatic endothelial permeability are blocked by doxycycline treatment. Cadaverine regulates biotin synthesis to modulate primary root growth in Arabidopsis Caenorhabditis elegans in microgravity: An omics perspective, Calcium, mechanical signaling, and tip growth, CAMDLES: CFD-DEM Simulation of Microbial Communities in Spaceflight and Artificial Microgravity Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties Celebrating 30 years of access to NASA space life sciences data, Celebrating 30 years of access to NASA space life sciences data., Cell type-specific imaging of calcium signaling in Arabidopsis thaliana seedling roots using GCaMP3. Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight. Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent. Changes in the distribution and function of leukocytes after whole-body iron ion irradiation. Characterization of Aspergillus fumigatus isolates from air and surfaces of the International Space Station Characterization of Aspergillus niger Isolated from the International Space Statio Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission. Characterization of metagenome-assembled genomes from the International Space Station, Characterization of metagenome-assembled genomes from the International Space Station., Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations. Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing Characterization of the Salmonella enterica serovar Typhimurium ydcI gene which encodes a conserved DNA binding protein required for full acid stress resistance. Characterization of the total and viable bacterial and fungal communities associated with the International Space Station surfaces Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation, Chronic skeletal unloading of the rat femur: mechanisms and functional consequences of vascular remodeling. Circulating miRNA spaceflight signature reveals targets for countermeasure development Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA), Comparative genomic analysis of Cohnella hashimotonis sp. nov. isolated from the International Space Station, Comparative genomic analysis of Cohnella hashimotonis sp. nov. isolated from the International Space Station. Comparative transcriptomics indicate changes in cell wall organization and stress response in seedlings during spacefligh Comparing RNA-Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight Comparison of Microgravity Analogs to Spaceflight in Studies of Plant Growth and Development Competitive Growth Assay of Mutagenized Chlamydomonas reinhardtii Compatible With the International Space Station Veggie Plant Growth Chamber. Complete Genome Sequence of Carnobacterium gilichinskyi Strain WN1359T (DSM 27470T) Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact Conducting plant experiments in space and on the Moon, Conservation of the low-shear modeled microgravity response in Enterobacteriaceae and analysis of the trp genes in this response. Conserved plant transcriptional responses to microgravity from two consecutive spaceflight experiments., Contributions of spore secondary metabolites to UV-C protection and virulence vary in different Aspergillus fumigatus strains Cortical thinning and structural bone changes in non-human primates after single-fraction whole-chest irradiation. Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction Crewmember microbiome may influence microbial composition of ISS habitable surface CubeSats for microbiology and astrobiology research Cultivation in space flight produces minimal alterations in the susceptibility of Bacillus subtilis cells to 72 different antibiotics and growth-inhibiting compound Cultivation of Staphylococcus epidermidis in the human spaceflight environment leads to alterations in the frequency and spectrum of spontaneous rifampicin-resistance mutations in the rpoB gen Cytoskeletal configuration modulates mechanically induced changes in mesenchymal stem cell osteogenesis, morphology, and stiffness. Cytoskeleton structure and total methylation of mouse cardiac and lung tissue during space flight Data for characterization of SALK_084889, a T-DNA insertion line of Arabidopsis thalian Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight, Desiccation mitigates heat stress in the resurrection fern, Pleopeltis polypodioides Desiccation of Hypsibius exemplaris, Designing a Novel Monitoring Approach for the Effects of Space Travel on Astronauts’ Health Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight Development and characterization of two porcine monocyte-derived macrophage cell lines., Development of otolith receptors in Japanese quail. Dichotomous effects on lymphatic transport with loss of caveolae in mice. Dietary countermeasure mitigates simulated spaceflight-induced osteopenia in mice Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation. Differential Single Cell Responses of Embryonic Stem Cells Versus Embryoid Bodies to Gravity Mechanostimulation Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses, Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth., Dose- and Ion-Dependent Effects in the Oxidative Stress Response to Space-Like Radiation Exposure in the Skeletal System Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats. Draft genome sequence of a clinical isolate of Fusarium fujikuroi isolated from a male patient with acute myeloid leukemia. Draft Genome Sequence of Solibacillus kalamii, Isolated from an Air Filter Aboard the International Space Station Draft genome sequence of Sphingomonas paucimobilis strain Sph5, isolated from tap water filtration membrane Draft Genome Sequences from a Novel Clade of Bacillus cereus Sensu Lato Strains, Isolated from the International Space Station. Draft Genome Sequences of Acinetobacter and Bacillus Strains Isolated from Spacecraft-Associated Surfaces Draft Genome Sequences of Aspergillus and Penicillium Species Isolated from the International Space Station and Crew Resupply Vehicle Capsul Draft Genome Sequences of Bacillaceae Strains Isolated from the International Space Station Draft genome sequences of biosafety level 2 opportunistic pathogens isolated from the environmental surfaces of the International Space Station Draft Genome Sequences of Enterobacteriales Strains Isolated from the International Space Station Draft Genome Sequences of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment Draft Genome Sequences of Klebsiella Species Isolated from the International Space Station Draft Genome Sequences of Lactobacillales Isolated from the International Space Station Draft Genome Sequences of Rhodotorula mucilaginosa Strains Isolated from the International Space Station Draft Genome Sequences of Several Fungal Strains Selected for Exposure to Microgravity at the International Space Station. Draft Genome Sequences of Sphingomonas Species Associated with the International Space Station Draft Genome Sequences of Tremellomycetes Strains Isolated from the International Space Station Draft genome sequences of two Aspergillus fumigatus strains, isolated from the International Space Station Draft genome sequences of two Fusarium oxysporum isolates cultured from infected Zinnia hybrida plants grown on the International Space Station. Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station Dried plum diet protects from bone loss caused by ionizing radiation Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids, Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids., Editorial: Revisiting the limits of plant life - plant adaptations to extreme terrestrial environments relating to astrobiology and space biology., Effect of leptin deficiency on the skeletal response to hindlimb unloading in adult male mice. Effect of simulated cosmic radiation on cytomegalovirus reactivation and lytic replication, Effect of simulated cosmic radiation on cytomegalovirus reactivation and lytic replication., Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability. Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function Effects of angular frequency during clinorotation on mesenchymal stem cell morphology and migration Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice Effects of liquid cultivation on gene expression and phenotype of C. elegans Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse hear Effects of mechanostimulation on gravitropism and signal persistence in flax roots. Effects of Sex and Gender on Adaptation to Space: Immune Syste Effects of sex and gender on adaptations to space: reproductive health Effects of simulated microgravity on the proteome and secretome of the polyextremotolerant black fungus Knufia chersonesos. Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice. Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice., Effects of Skeletal Unloading on the Vasomotor Properties of the Rat Femur Principal Nutrient Artery Effects of Space Flight on Inflammasome Activation in the Brain of Mice., Effects of space flight on mouse liver versus kidney: Gene pathway analyses. Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice Effects of Spaceflight on Cancellous and Cortical Bone in Proximal Femur in Growing Rats Effects of spaceflight on the brain, Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice Effects of spaceflight on the mouse submandibular gland, Effects of spaceflight on the muscles of the murine shoulder. Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization Enabling clonal analyses of yeast in outer space by encapsulation and desiccation in hollow microparticles. Endocrine Effects of Space Flight, Endoplasmic reticulum-shape and function in stress translatio Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis, Environmental cues and symbiont microbe-associated molecular patterns function in concert to drive the daily remodelling of the crypt-cell brush border of the Euprymna scolopes light organ Environmental dependence of competitive fitness in rifampin-resistant rpoB mutants of Bacillus subtilis. Epigenomic regulators elongator complex subunit 2 and methyltransferase 1 differentially condition the spaceflight response in Arabidopsis ERULUS is a plasma membrane-localized receptor-like kinase that specifies root hair growth by maintaining tip-focused cytoplasmic calcium oscillations. Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line Ethical considerations for the age of non-governmental space exploration, Ethylene-induced flavonol accumulation in guard cells suppresses reactive oxygen species and modulates stomatal aperture EUK-134 ameliorates nNOSµ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading. Evaluating ocular response in the retina and optic nerve head after single and fractionated high-energy protons Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium Evaluating the lettuce metatranscriptome with MinION sequencing for future spaceflight food production applications Evaluation of in vitro macrophage differentiation during space flight Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days) Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station Evidence of spaceflight-induced adverse effects on photoreceptors and retinal function in the mouse eye., Exercise training augments regional bone and marrow blood flow during exercise Experimental Evolution of Bacillus subtilis Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice, Exploration of space to achieve scientific breakthroughs Exposure of Bacillus subtilis to low pressure (5 kilopascals) induces several global regulons, including those involved in the SigB-mediated general stress response Exposure of Mycobacterium marinum to low-shear modeled microgravity: Effect on growth, the transcriptome and survival under stress. Expressing and Characterizing Mechanosensitive Channels in Xenopus Oocytes Expression and characterization of the bacterial mechanosensitive channel MscS in Xenopus laevis oocytes Extracellular nucleotides elicit cytosolic free calcium oscillations in Arabidopsis. Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review FAIRness and usability for open-access omics data systems. Failure to Generate Bone Marrow Adipocytes Does Not Protect Mice from Ovariectomy-Induced Osteopeni Fifteen days of microgravity causes growth in calvaria of mice Focal enhancement of the skeleton to exercise correlates to mesenchymal stem cell responsivity rather than peak external forces. From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009. From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions. Functional changes in the snail statocyst system elicited by microgravity Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana., Fundamental plant biology enabled by the space shuttle. Fungal diversity differences in the indoor dust microbiome from built environments on Earth and in space., Galactose-depleted xycoglucan is dysfunctional and leads to dwarfism in Arabidopsis GeneLab database analyses suggest long-term impact of space radiation on the cardiovascular system by the activation of FYN through reactive oxygen species. GeneLab: Omics database for spaceflight experiments Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight. Genetic and tissue level muscle-bone interactions during unloading and reambulation. Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight, Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station, Genomic and functional characterization of Enterococcus faecalis isolates recovered from the International Space Station and their potential for pathogenicity Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station, Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities., Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station Genomic Characterization of Potential Plant Growth-Promoting Features of Sphingomonas Strains Isolated from the International Space Station Genomic Characterization of the Titan-like Cell Producing Naganishia tulchinskyi, the First Novel Eukaryote Isolated from the International Space Station Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station, Glutamate triggers long-distance, calcium-based plant defense signaling., Gravitropic signaling in plants Gravitropism and lateral root emergence are dependent on the trans-Golgi network protein TNO1 Gravitropism and mechanical signaling in plants., Gravity signaling in flowering plant roots, Growth and antifungal resistance of the pathogenic yeast, Candida albicans, in the microgravity environment of the International Space Station: An aggregate of multiple flight experiences. Growth chambers on the International Space Station for large plants, Growth of Carnobacterium spp. from permafrost under low pressure, temperature, and anoxic atmosphere has implications for Earth microbes on Mars Growth performance and root transcriptome remodeling of Arabidopsis in response to Mars-like levels of magnesium sulfate. Hardware validation of the Advanced Plant Habitat on ISS: Canopy photosynthesis in reduced gravity. High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core "DSB" response specific to clastogenic treatments High-gradient magnetic fields and starch metabolism: Results from a space experiment. High-precision method for cyclic loading of small-animal vertebrae to assess bone quality. Hindlimb suspension in Wistar rats: Sex-based differences in muscle response Hindlimb Unloading: Rodent Analog for Microgravity, HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis Homotypic vacuole fusion requires VTI11 and is regulated by phosphoinositides Host-microbe interactions in microgravity: assessment and implications. HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight. Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons Human presence impacts fungal diversity of inflated lunar/Mars analog habitat. Hypergravity disruption of homeorhetic adaptations to lactation in rat dams include changes in circadian clock Hyperoxia inhibits T cell activation in mice, Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets. Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection, Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections Identification of metagenome-assembled genomes containing antimicrobial resistance genes, isolated from an advanced water treatment facility Immune suppressive extracellular vesicle proteins of Leptopilina heterotoma are encoded in the wasp genome Immunization induces inflammation in the mouse heart during spaceflight. Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis. Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length., In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation–Polar–Cation Clip Motif in Knottin Proteins In situ linkage of fungal and bacterial proliferation to microbiologically influenced corrosion in B20 biodiesel storage tanks. In situ monitoring of barrier function on-chip via automated, non-invasive luminescence sensing., In situ resource utilisation: The potential for space biominin In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds Increasing the number of unloading/reambulation cycles does not adversely impac body composition and lumbar bone mineral density but reduces tissue sensitivity Induction of attachment-independent biofilm formation and repression of Hfq expression by low-fluid-shear culture of Staphylococcus aureus Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats., Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1g on the Structure and Function of the Utricle in Toadfish, Opsanus tau. Influence of social isolation during prolonged simulated weightlessness by hindlimb unloading Influence of the spaceflight environment on macrophage lineages, Inhibition of Cytomegalovirus by Pentacta pygmaea Fucosylated Chondroitin Sulfate Depends on Its Molecular Weight, Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine sulfated glycans. Innate immune responses of Drosophila melanogaster are altered by spaceflight. Inspiration4 data access through the NASA Open Science Data Repository Inspiration4 data access through the NASA Open Science Data Repository Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans. Interplay of space radiation and microgravity in DNA damage and DNA damage response Inter-regulation of the unfolded protein response and auxin signaling Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression Investigation of Spaceflight Induced Changes to Astronaut Microbiomes Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissu IRE1: ER stress sensor and cell fate executor Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism KatharoSeq enables high-throughput microbiome analysis from low-biomass sample Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Disease Lab-on-a-chip approaches for space-biology research. Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cell Leptin and environmental temperature as determinants of bone marrow adiposity in female mic Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism Lifelong wheel running exercise and mild caloric restriction attenuate nuclear EndoG in the aging plantaris muscle Light and gravity signals synergize in modulating plant developmen Lipid rafts and plant gravisensitivity Longitudinal characterization of multispecies microbial populations recovered from spaceflight potable wate Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight, Longitudinal time course of muscle impairments during partial weight-bearing in rats Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture Low-speed clinorotation of Brachypodium distachyon and Arabidopsis thaliana seedlings triggers root tip curvatures that are reminiscent of gravitropism Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing. Maintaining the factory: The roles of the unfolded protein response in cellular homeostasis in plants. Maintenance of near normal bone mass and architecture in lethally irradiated female mice following adoptive transfer with as few as 750 purified hematopoietic stem cells. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight Manipulating the permeation of charged compounds through the MscL nanovalve. MARSBOx: Fungal and bacterial endurance from a balloon-flown analog mission in the stratosphere Mechanotransduction in Prokaryotes: A Possible Mechanism of Spaceflight Adaptation Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics., Metabolic modeling of the International Space Station microbiome reveals key microbial interactions Metabolomic profiling of the secretome from human neural stem cells flown into space., Metabolomics profile of the secretome of space-flown oligodendrocytes., Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential., MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communitie Methylobacterium ajmalii sp. nov., isolated from the International Space Station Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae. Mice in Bion-M 1 space mission: training and selectio Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions, Microbial Burden Estimation of Food Items, Built Environments, and the International Space Station Using Film Media Microbial Characteristics of ISS Environmental Surfaces Microbial existence in controlled habitats and their resistance to space conditions, Microbial tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station. Microbiological and nutritional analysis of lettuce crops grown on the International Space Station Microbiome metadata standards: Report of the National Microbiome Data Collaborative's workshop and follow-on activities. Microbiomes of the dust particles collected from the International Space Station and Spacecraft assembly facilities Microfluidic Device for Studying Nematodes Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics. Microfluidics-integrated spaceflight hardware for measuring muscle strength of Caenorhabditis elegans on the International Space Station. Microgravity alters the expression of salivary proteins Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells. Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21 Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cell Microgravity Stress: Bone and Connective Tissue, Microgravity validation of a novel system for RNA isolation and multiplex quantitative real time PCR analysis of gene expression on the International Space Station Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa. Mitigation and use of biofilms in space for the benefit of human space exploration, Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans., Mitochondria-targeted human catalase in the mouse longevity MCAT model mitigates head-tilt bedrest-induced neuro-inflammation in the hippocampus. MnSOD Overexpression Reduces Fibrosis and Pro-Apoptotic Signaling in the Aging Mouse Heart Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis Modeled microgravity alters lipopolysaccharide and outer membrane vesicle production of the beneficial symbiont Vibrio fischeri Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age. Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew, Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates Molecular muscle experiment: Hardware and operational lessons for future astrobiology space experiments Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mic Morphology of Penicillium rubens Biofilms Formed in Space, Morphology of the Utricular Otolith Organ in the Toadfish, Opsanus tau Multi-analyte biochip (MAB) based on all-solid-state ion-selective electrodes (ASSISE) for physiological research Multi-drug resistant Enterobacter bugandensis species isolated from the International Space Station and comparative genomic analyses with human pathogenic strains Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse live Multiparameter behavioral analyses provide insights to mechanisms of cyanide resistance in Caenorhabditis elegans. Multiscale effects of spaceflight on murine tendon and bone Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice. n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial NADPH oxidase activity is required for ER stress survival in plants. NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions. NASA GeneLab platform utilized for biological response to space radiation in animal model NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Data NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Dat NASA GeneLab: Interfaces for the exploration of space omics data NASA open science data repository: Open science for life in space., Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length responses to cadaverine in Arabidopsis. Nature of pre-earthquake phenomena and their effects on living organisms NemaFlex: A microfluidics-based technology for standardized measurement of muscular strength of C. elegans. NemaLife chip: a micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans Network Analysis of Gene Transcriptions of Arabidopsis thaliana in Spaceflight Microgravity. Neutrophil to Lymphocyte ratio: A biomarker to monitor the immune status of astronauts. New device for high-throughput viability screening of flow biofilms New insights into lignification via network and multi-omics analyses of arogenate dehydratase knock-out mutants in Arabidopsis thalian New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli New perspectives on viable microbial communities in low-biomass cleanroom environments Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after Space Flight Orchestrating rapid long-distance signaling in plants with Ca2+ , ROS, and electrical signals Organization of the ER-Golgi interface for membrane traffic control. Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions., Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight. Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation. Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism Oxygen dependency of germinating Brassica seeds. Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass Partial weight suspension: A novel murine model for investigating adaptation to reduced musculoskeletal loading. Pectin methylesterification impacts the relationship between photosynthesis and plant growth Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening Phenotypic characterization of an Arabidopsis T- DNA insertion line SALK_06350 Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants Phosphoinositide-signaling is one component of a robust plant defense response Phototropism of Arabidopsis thaliana in microgravity and fractional gravity on the International Space Station. Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes, Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states. Plant cell proliferation and growth are altered by microgravity conditions in spaceflight. Plant chemical genomics: gravity sensing and response., Plant growth strategies are remodeled by spaceflight, Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissue Plastid osmotic stress influences cell differentiation at the plant shoot apex Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression. Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station, Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station., Preservation of Multiple Mammalian Tissues to Maximize Science Return from Ground Based and Spaceflight Experiments Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins. Protective alleles and precision healthcare in crewed spaceflight Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function, Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function., Proteomic analysis of mouse brain subjected to spaceflight. Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation, Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station. Proteomic study of microsomal proteins reveals a key role for Arabidopsis Annexin 1 in mediating heat stress-induced increase in intracellular calcium levels. Rad-Bio-App: A discovery environment for biologists to explore spaceflight-related radiation exposure Rapid phenotypic response of LSMMG-'primed' Candida albicans., Reactivation of Latent Epstein-Barr Virus: A Comparison after Exposure to Gamma, Proton, Carbon, and Iron Radiation Real-time In Vivo Recording of Arabidopsis Calcium Signals During Insect Feeding Using a Fluorescent Biosenso Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinemen Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture. Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018). Red light enhances plant adaptation to spaceflight and Mars g-levels Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spacefligh Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolis Reduced Chloroplast Coverage genes from Arabidopsis thaliana help to establish the size of the chloroplast compartmen Regulation of hemocytes in Drosophila requires dappled cytochrome b5. Regulation of plant gravity sensing and signaling by the actin cytoskeleton. REGULATOR OF BULB BIOGENESIS1 (RBB1) Is Involved in Vacuole Bulb Formation in Arabidopsis. Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response, Relevance of the Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis Reply to Bemm et al. and Arakawa: Identifying foreign genes in independent Hypsibius dujardini genome assemblies Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight. Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification Response of Arabidopsis thaliana and Mizuna mustard seeds to simulated space radiation exposures Response of the mouse sublingual gland to spaceflight RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques RNAseq analysis of the response of Arabidopsis thaliana to fractional gravity under blue-light stimulation during spacefligh RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice Role of oestrogen receptor signaling in skeletal response to leptin in female ob/ob mice. Role of shear stress on renal proximal tubular cells for nephrotoxicity assays Roll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D media Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss. Root growth movements: Waving and skewing. Root skewing-associated genes impact the spaceflight response of Arabidopsis thaliana. ROS, calcium and electric signals: Key mediators of rapid systemic signaling in plants Routine omics collection is a golden opportunity for European human research in space and analog environments. S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins Safety and pharmacokinetics of intranasally administered heparin Salivary Gland Protein Expression after Bion-M1 and Space Shuttle STS-135 Missions Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants. Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight, Sex differences in muscle health in simulated micro- and partial-gravity environments in rats., Sex-specific cardiovascular adaptations to simulated microgravity in Sprague-Dawley rats, Sierra Nevada sweep: Metagenomic measurements of bioaerosols vertically distributed across the troposphere. Sigma S-dependent antioxidant defense protects stationary-phase Escherichia coli against the bactericidal antibiotic gentamicin Simulated micro-, lunar, and Martian gravities on Earth—effects on Escherichia coli growth, phenotype, and sensitivity to antibiotics. Simulated microgravity alters gene regulation linked to immunity and cardiovascular disease, Simulated microgravity alters gene regulation linked to immunity and cardiovascular disease., Simulated Microgravity Enhances Oligodendrocyte Mitochondrial Function and Lipid Metabolis Simulated microgravity impairs human NK [natural killer] cell cytotoxic activity against space radiation-relevant leukemic cells Simulated microgravity impairs human NK [natural killer] cell cytotoxic activity against space radiation-relevant leukemic cells., Simulated microgravity induces regionally distinct neurovascular and structural remodeling of skeletal muscle and cutaneous arteries in the rat Simulated Microgravity Promotes Horizontal Gene Transfer of Antimicrobial Resistance Genes between Bacterial Genera in the Absence of Antibiotic Selective Pressur Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight, Skeletal tissue regulation by catalase over-expression in mitochondria Skewing in Arabidopsis roots involves disparate environmental signaling pathways. Small changes in thermoregulation influence cancellous bone turnover balance in distal femur metaphysis in growing female mice, Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space Space radiation damage rescued by inhibition of key spaceflight associated miRNAs, Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver Spaceflight Activates Lipotoxic Pathways in Mouse Liver Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans Spaceflight alters expression of microRNA during T-cell activatio Spaceflight alters host-gut microbiota interactions Spaceflight alters host-gut microbiota interactions. Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscl Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodent Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retin Spaceflight enhances cell aggregation and random budding in Candida albicans. Spaceflight Induces Specific Alterations in the Proteomes of Arabidopsi Spaceflight Induces Strength Decline in Caenorhabditis elegans, Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment, Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment, Spaceflight induces changes in gene expression profiles linked to insulin and estrogen, Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses. Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina. Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice Spaceflight promotes biofilm formation by Pseudomonas aeruginosa. Spaceflight transcriptomes: unique responses to a novel environment., Spaceflight-associated vascular remodeling and gene expression in mouse calvaria. Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: Implications for elevated cerebral perfusion and intracranial pressure Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana. Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments. Spaceflight-induced gene expression profiles in the mouse brain are attenuated by treatment with the antioxidant BuOE, Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle. Spaceflight-induced vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation Spatial and temporal characteristics of vestibular convergence Spatial and temporal localization of SPIRRIG and WAVE/SCAR reveal roles for these proteins in actin-mediated root hair development. Spatial Characterization of Microbial Communities on Multi-Species Leafy Greens Grown Simultaneously in the Vegetable Production Systems on the International Space Station Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight, Spatial omics technologies at multimodal and single cell/subcellular level. Spatial regulation of a common precursor from two distinct genes generates metabolite diversity Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice, Spatiotemporal expression and control of haemoglobin in space, Stem Cell Health and Tissue Regeneration in Microgravity, Strategies, research priorities, and challenges for the exploration of space beyond low-Earth orbit, Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice. Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration Symbiotic organs shaped by distinct modes of genome evolution in cephalopods. Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation., Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathway Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing, Test of Arabidopsis Space Transcriptome: A discovery environment to explore multiple plant biology spaceflight experiments. The 14-3-3 proteins of Arabidopsis regulate root growth and chloroplast development as components of the photosensory system The biology of tardigrade disordered proteins in extreme stress tolerance., The cyclic nucleotide-gated channel CNGC14 regulates root gravitropism in Arabidopsis thaliana., The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus. The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface The Effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment. The effect of spaceflight on the gravity-sensing auxin gradient of roots: GFP reporter gene microscopy on orbit The fast and the furious: Rapid long-range signaling in plants The impact of SRT2104 on skeletal muscle mitochondrial function, redox biology, and loss of muscle mass in hindlimb unloaded rats. The importance of Earth reference controls in spaceflight-omics research: Characterization of nucleolin mutants from the Seedling Growth experiment The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcome The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivatio The interaction of vortical flows with red cells in venous valve mimics The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo. The ongoing search for the molecular basis of plant osmosensing The partial weight-bearing rat model using a pelvic harness does not impact stress or hindlimb blood flow., The Plant Health Monitoring System of the EDEN ISS Space Greenhouse in Antarctica during the 2018 experiment phase The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. The smallest space miners: Principles of space biomining The Space Omics and Medical Atlas (SOMA) and international astronaut biobank, The vacuolar H+/Ca transporter CAX1 participates in submergence and anoxia stress responses. Thermoneutral housing attenuates premature cancellous bone loss in male C57BL/6J mice Three routes to modulate the pore size of the MscL channel/nanovalve Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns. TNO1 is involved in salt tolerance and vacuolar trafficking in Arabidopsis TNO1, a TGN-localized SNARE-interacting protein, modulates root skewing in Arabidopsis thaliana To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants, To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants., To Infinity and Beyond! Human spaceflight and life science Toll mediated infection response is altered by gravity and spaceflight in Drosophila Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana. Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target Toward sustainable space exploration: a roadmap for harnessing the power of microorganisms., Toward sustainable space exploration: A roadmap for harnessing the power of microorganisms., Transcription profile of auxin related genes during positively gravitropic hypocotyl curvature of Brassica rapa. Transcriptional and Hormonal Regulation of Gravitropism of Woody Stems in Populus Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen. Transcriptome and proteome responses in RNAlater preserved tissue of Arabidopsis thaliana. Transcriptomic effects on the mouse heart following 30 days on the International Space Station. Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology. Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology. Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences Treatment with a soluble bone morphogenetic protein type 1A receptor (BMPR1A) fusion protein increases bone mass and bone formation in mice subjected to hindlimb unloading Trimeric structure of (+)-pinoresinol-forming dirigent protein at 1.95 A resolution with three isolated active sites Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat Uncovering transcriptional responses to fractional gravity in Arabidopsis root Understanding macrophage differentiation during space flight: The importance of ground-based experiments before space fligh Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Mission Unfolded protein response in plants: one master, many questions United in Diversity: Mechanosensitive Ion Channels in Plant Utilization of single‐image normalized difference vegetation index (SI‐NDVI) for early plant stress detectio Utilizing the KSC fixation tube to conduct human-tended plant biology experiments on a suborbital spacefligh Validation of a new Rodent experimental System to investigate consequences of Long Duration Space Habitatio Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the International Space Station Vesicles versus Tubes: Is Endoplasmic Reticulum-Golgi Transport in Plants Fundamentally Different from Other Eukaryotes Vive la radiorésistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization Whole metagenome profiles of particulates collected from the International Space Statio Wortmannin-induced vacuole fusion enhances amyloplast dynamics in Arabidopsis zigzag1 hypocotyls Yeast in Space Mice in Bion-M 1 space mission: training and selection
Microgravity induces pelvic bone loss through osteoclastic activity, osteocytic osteolysis, and osteoblastic cell cycle inhibition by CDKN1a/p21
Stem Cell Health and Tissue Regeneration in Microgravity
Microgravity Reduces the Differentiation and Regenerative Potential of Embryonic Stem Cells
Microgravity validation of a novel system for RNA isolation and multiplex quantitative real time PCR analysis of gene expression on the International Space Station
Spaceflight Modulates the Expression of Key Oxidative Stress and Cell Cycle Related Genes in Heart
Dose- and Ion-Dependent Effects in the Oxidative Stress Response to Space-Like Radiation Exposure in the Skeletal System
From the bench to exploration medicine: NASA life sciences translational research for human exploration and habitation missions.
High-precision method for cyclic loading of small-animal vertebrae to assess bone quality.
Effects of ex vivo ionizing radiation on collagen structure and whole-bone mechanical properties of mouse vertebrae.
Absence of gamma-sarcoglycan alters the response of p70S6 kinase to mechanical perturbation in murine skeletal muscle
AtRabD2b and AtRabD2c have overlapping functions in pollen development and pollen tube growth.
TNO1 is involved in salt tolerance and vacuolar trafficking in Arabidopsis.
Functional redundancy between trans-Golgi network SNARE family members in Arabidopsis thaliana.
Root growth movements: Waving and skewing.
Gravitropism and lateral root emergence are dependent on the trans-Golgi network protein TNO1
TNO1, a TGN-localized SNARE-interacting protein, modulates root skewing in Arabidopsis thaliana.
The Drosophila SUN protein Spag4 cooperates with the coiled-coil protein Yuri Gagarin to maintain association of the basal body and spermatid nucleus.
Toll mediated infection response is altered by gravity and spaceflight in Drosophila
Multi-omics analysis of multiple missions to space reveal a theme of lipid dysregulation in mouse liver
GeneLab database analyses suggest long-term impact of space radiation on the cardiovascular system by the activation of FYN through reactive oxygen species.
FAIRness and usability for open-access omics data systems.
NASA GeneLab platform utilized for biological response to space radiation in animal models
Circulating miRNA spaceflight signature reveals targets for countermeasure development
Machine learning algorithm to characterize antimicrobial resistance associated with the International Space Station surface microbiome
Extraterrestrial Gynecology: Could Spaceflight Increase the Risk of Developing Cancer in Female Astronauts? An Updated Review
Muscle atrophy phenotype gene expression during spaceflight is linked to a metabolic crosstalk in both the liver and the muscle in mice.
Chromosomal positioning and epigenetic architecture influence DNA methylation patterns triggered by galactic cosmic radiation
A comprehensive SARS-CoV-2 and COVID-19 review, Part 2: Host extracellular to systemic effects of SARS-CoV-2 infection
Aging and putative frailty biomarkers are altered by spaceflight
Space radiation damage rescued by inhibition of key spaceflight associated miRNAs
Ethical considerations for the age of non-governmental space exploration
Innate immune responses of Drosophila melanogaster are altered by spaceflight.
Prolonged Exposure to Microgravity Reduces Cardiac Contractility and Initiates Remodeling in Drosophila
Regulation of plant gravity sensing and signaling by the actin cytoskeleton.
HLB1 Is a Tetratricopeptide Repeat Domain-Containing Protein That Operates at the Intersection of the Exocytic and Endocytic Pathways at the TGN/EE in Arabidopsis
ERULUS is a plasma membrane-localized receptor-like kinase that specifies root hair growth by maintaining tip-focused cytoplasmic calcium oscillations.
Brassinosteroids inhibit autotropic root straightening by modifying filamentous-actin organization and dynamics.
Cell type-specific imaging of calcium signaling in Arabidopsis thaliana seedling roots using GCaMP3.
Spatial and temporal localization of SPIRRIG and WAVE/SCAR reveal roles for these proteins in actin-mediated root hair development.
Microgravity Stress: Bone and Connective Tissue
S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: implications for detergent-solubilized membrane proteins
Manipulating the permeation of charged compounds through the MscL nanovalve.
The oligomeric state of the truncated mechanosensitive channel of large conductance shows no variance in vivo.
Three routes to modulate the pore size of the MscL channel/nanovalve
The dynamics of protein-protein interactions between domains of MscL at the cytoplasmic-lipid interface
The MscS and MscL families of mechanosensitive channels act as microbial emergency release valves
Chimeras reveal a single lipid-interface residue that controls MscL channel kinetics as well as mechanosensitivity
Evidence for extensive horizontal gene transfer from the draft genome of a tardigrade
Reply to Bemm et al. and Arakawa: Identifying foreign genes in independent Hypsibius dujardini genome assemblies
Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation.
Desiccation of Hypsibius exemplaris
The biology of tardigrade disordered proteins in extreme stress tolerance.
Production of reactive oxygen species and involvement of bioprotectants during anhydrobiosis in the tardigrade Paramacrobiotus spatialis
Partial weight suspension: A novel murine model for investigating adaptation to reduced musculoskeletal loading.
Partial reductions in mechanical loading yield proportional changes in bone density, bone architecture, and muscle mass
Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscle
Spaceflight Activates Lipotoxic Pathways in Mouse Liver
Treatment with a soluble bone morphogenetic protein type 1A receptor (BMPR1A) fusion protein increases bone mass and bone formation in mice subjected to hindlimb unloading.
RNAseq and RNA molecular barcoding reveal differential gene expression in cortical bone following hindlimb unloading in female mice
Proteomic and phosphoproteomic characterization of cardiovascular tissues after long term exposure to simulated space radiation
Adaptive Changes in the Vestibular System of Land Snail to a 30-Day Spaceflight and Readaptation on Return to Earth
Morphology of the Utricular Otolith Organ in the Toadfish, Opsanus tau
Influence of Magnitude and Duration of Altered Gravity and Readaptation to 1g on the Structure and Function of the Utricle in Toadfish, Opsanus tau.
Organization of the ER-Golgi interface for membrane traffic control.
IRE1: ER stress sensor and cell fate executor.
Inter-regulation of the unfolded protein response and auxin signaling.
Endoplasmic reticulum-shape and function in stress translation
Galactose-depleted xycoglucan is dysfunctional and leads to dwarfism in Arabidopsis
Unfolded protein response in plants: one master, many questions.
Vesicles versus Tubes: Is Endoplasmic Reticulum-Golgi Transport in Plants Fundamentally Different from Other Eukaryotes?
Pectin methylesterification impacts the relationship between photosynthesis and plant growth.
Reduced Chloroplast Coverage genes from Arabidopsis thaliana help to establish the size of the chloroplast compartment
Maintaining the factory: The roles of the unfolded protein response in cellular homeostasis in plants.
NADPH oxidase activity is required for ER stress survival in plants.
Relevance of the Unfolded Protein Response to Spaceflight-Induced Transcriptional Reprogramming in Arabidopsis
Reanalysis of the Mars500 experiment reveals common gut microbiome alterations in astronauts induced by long-duration confinement
High atomic weight, high-energy radiation (HZE) induces transcriptional responses shared with conventional stresses in addition to a core "DSB" response specific to clastogenic treatments
Genomic stability in response to high versus low linear energy transfer radiation in Arabidopsis thaliana
Acceleration profiles and processing methods for parabolic flight.
Cytoskeleton structure and total methylation of mouse cardiac and lung tissue during space flight.
Toward countering muscle and bone loss with spaceflight: GSK3 as a potential target
Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment
Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties
Inter-agency perspective: Translating advances in biomarker discovery and medical countermeasures development between terrestrial and space radiation environments
Genomic and functional characterization of Enterococcus faecalis isolates recovered from the International Space Station and their potential for pathogenicity
Evaluation of in vitro macrophage differentiation during space flight.
Identification of critical host mitochondrion-associated genes during Ehrlichia chaffeensis infections
Ehrlichia chaffeensis replication sites in adult Drosophila melanogaster.
Development and characterization of two porcine monocyte-derived macrophage cell lines.
Understanding macrophage differentiation during space flight: The importance of ground-based experiments before space flight
Bone marrow leptin signaling mediates obesity-associated adipose tissue inflammation in male mice.
Establishment and characterization of DB-1: a leptin receptor-deficient murine macrophage cell line
Validation of methods to assess the immunoglobulin gene repertoire in tissues obtained from mice on the International Space Station.
Characterization of the naive murine antibody repertoire using unamplified high-throughput sequencing
Effects of spaceflight on the immunoglobulin repertoire of unimmunized C57BL/6 mice
A comparison of unamplified and massively multiplexed PCR amplification for murine antibody repertoire sequencing.
Effects of skeletal unloading on the antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.
Effects of skeletal unloading on the bone marrow antibody repertoire of tetanus toxoid and/or CpG treated C57BL/6J mice.
An Analysis of the Effects of Spaceflight and Vaccination on Antibody Repertoire Diversity
Effects of spaceflight aboard the International Space Station on mouse estrous cycle and ovarian gene expression
Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability.
Spaceflight promotes biofilm formation by Pseudomonas aeruginosa.
GeneLab: Omics database for spaceflight experiments
NASA GeneLab: Interfaces for the exploration of space omics data
Comprehensive multi-omics analysis reveals mitochondrial stress as a central biological hub for spaceflight impact
A New Era for Space Life Science: International Standards for Space Omics Processing
Knowledge Network Embedding of Transcriptomic Data from Spaceflown Mice Uncovers Signs and Symptoms Associated with Terrestrial Diseases
NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Data
Spatially resolved multiomics on the neuronal effects induced by spaceflight in mice
Biological horizons: pioneering open science in the cosmos
Inspiration4 data access through the NASA Open Science Data Repository
NASA GeneLab derived microarray studies of Mus musculus and Homo sapiens organisms in altered gravitational conditions.
Celebrating 30 years of access to NASA space life sciences data
Dichotomous effects on lymphatic transport with loss of caveolae in mice.
Fungal diversity differences in the indoor dust microbiome from built environments on Earth and in space.
Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station
Aging and estrogen status: A possible endothelium-dependent vascular coupling mechanism in bone remodeling.
Chronic skeletal unloading of the rat femur: mechanisms and functional consequences of vascular remodeling.
Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation.
Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice.
Spaceflight-induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: Implications for elevated cerebral perfusion and intracranial pressure
Exercise training augments regional bone and marrow blood flow during exercise.
Effects of Skeletal Unloading on the Vasomotor Properties of the Rat Femur Principal Nutrient Artery
Type 2 diabetes alters bone and marrow blood flow and vascular control mechanisms in the ZDF rat.
Spaceflight on the Bion-M1 biosatellite alters cerebral artery vasomotor and mechanical properties in mice
Apollo Lunar Astronauts Show Higher Cardiovascular Disease Mortality: Possible Deep Space Radiation Effects on the Vascular Endothelium
Effects of age and exercise training on coronary microvascular smooth muscle phenotype and function
Impact of Spaceflight and Artificial Gravity on the Mouse Retina: Biochemical and Proteomic Analysis.
Simulated microgravity induces regionally distinct neurovascular and structural remodeling of skeletal muscle and cutaneous arteries in the rat
Spaceflight decelerates the epigenetic clock orchestrated with a global alteration in DNA methylome and transcriptome in the mouse retina
Development of otolith receptors in Japanese quail.
Spatial and temporal characteristics of vestibular convergence
Bone remodeling is regulated by inner ear vestibular signals
Simulated Microgravity Enhances Oligodendrocyte Mitochondrial Function and Lipid Metabolism
Human Neural Stem Cells Flown into Space Proliferate and Generate Young Neurons
Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight
Space Microgravity Alters Neural Stem Cell Division: Implications for Brain Cancer Research on Earth and in Space
Oligodendrocyte Progenitors Display Enhanced Proliferation and Autophagy after Space Flight
Metabolomics profile of the secretome of space-flown oligodendrocytes.
Metabolomic profiling of the secretome from human neural stem cells flown into space.
Strategies, research priorities, and challenges for the exploration of space beyond low-Earth orbit
Spaceflight Induces Specific Alterations in the Proteomes of Arabidopsis
The effect of spaceflight on the gravity-sensing auxin gradient of roots: GFP reporter gene microscopy on orbit.
Skewing in Arabidopsis roots involves disparate environmental signaling pathways.
Data for characterization of SALK_084889, a T-DNA insertion line of Arabidopsis thaliana
Genetic dissection of the Arabidopsis spaceflight transcriptome: Are some responses dispensable for the physiological adaptation of plants to spaceflight?
Phenotypic characterization of an Arabidopsis T- DNA insertion line SALK_063500
Utilization of single‚Äêimage normalized difference vegetation index (SI‚ÄêNDVI) for early plant stress detection
Comparing RNA-Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight.
Spaceflight-induced alternative splicing during seedling development in Arabidopsis thaliana.
The Plant Health Monitoring System of the EDEN ISS Space Greenhouse in Antarctica during the 2018 experiment phase
Root skewing-associated genes impact the spaceflight response of Arabidopsis thaliana.
Articular cartilage and sternal fibrocartilage respond differently to extended microgravity.
Host-microbe interactions in microgravity: assessment and implications.
Environmental cues and symbiont microbe-associated molecular patterns function in concert to drive the daily remodelling of the crypt-cell brush border of the Euprymna scolopes light organ
Symbiotic organs shaped by distinct modes of genome evolution in cephalopods.
Modeled microgravity alters lipopolysaccharide and outer membrane vesicle production of the beneficial symbiont Vibrio fischeri
Emergence of novel cephalopod gene regulation and expression through large-scale genome reorganization
Modeled microgravity alters apoptotic gene expression and caspase activity in the squid-vibrio symbiosis
In vitro generation of mechanically functional cartilage grafts based on adult human stem cells and 3D-woven poly(epsilon-caprolactone) scaffolds
Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds
Microbiome metadata standards: Report of the National Microbiome Data Collaborative's workshop and follow-on activities.
Spaceflight alters host-gut microbiota interactions
Asparagine biosynthesis as a mechanism of increased host lethality induced by Serratia marcescens in simulated microgravity environments
Comparative genomic analysis of Cohnella hashimotonis sp. nov. isolated from the International Space Station.
Characterization of metagenome-assembled genomes from the International Space Station
Biocontrol in built environments to reduce pathogen exposure and infection risk.
Extracellular nucleotides elicit cytosolic free calcium oscillations in Arabidopsis.
Calcium, mechanical signaling, and tip growth
Gravitropism and mechanical signaling in plants.
Salt stress-induced Ca2+ waves are associated with rapid, long-distance root-to-shoot signaling in plants.
Gravitropic signaling in plants
Wortmannin-induced vacuole fusion enhances amyloplast dynamics in Arabidopsis zigzag1 hypocotyls.
A ROS-assisted calcium wave dependent on AtRBOHD and TPC1 propagates the systemic response to salt stress in Arabidopsis roots
ROS, calcium and electric signals: Key mediators of rapid systemic signaling in plants
Real-time In Vivo Recording of Arabidopsis Calcium Signals During Insect Feeding Using a Fluorescent Biosensor
Orchestrating rapid long-distance signaling in plants with Ca2+ , ROS, and electrical signals
Glutamate triggers long-distance, calcium-based plant defense signaling.
Test of Arabidopsis Space Transcriptome: A discovery environment to explore multiple plant biology spaceflight experiments.
Tonoplast-localized Ca2+ pumps regulate Ca2+ signals during pattern-triggered immunity in Arabidopsis thaliana.
The fast and the furious: Rapid long-range signaling in plants.
Rad-Bio-App: A discovery environment for biologists to explore spaceflight-related radiation exposures
The vacuolar H+/Ca transporter CAX1 participates in submergence and anoxia stress responses.
Meta-analysis of the space flight and microgravity response of the Arabidopsis plant transcriptome
Low-dose, ionizing radiation and age-related changes in skeletal microarchitecture
Ionizing Radiation Stimulates Expression of Pro-Osteoclastogenic Genes in Marrow and Skeletal Tissue
Preservation of Multiple Mammalian Tissues to Maximize Science Return from Ground Based and Spaceflight Experiments
Hindlimb Unloading: Rodent Analog for Microgravity
Redox Signaling and Its Impact on Skeletal and Vascular Responses to Spaceflight
Influence of social isolation during prolonged simulated weightlessness by hindlimb unloading
Validation of a new Rodent experimental System to investigate consequences of Long Duration Space Habitation
Skeletal tissue regulation by catalase over-expression in mitochondria
Overexpression of catalase in mitochondria mitigates changes in hippocampal cytokine expression following simulated microgravity and isolation.
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis
Novel Organelles with Elements of Bacterial and Eukaryotic Secretion Systems Weaponize Parasites of Drosophila
A combined computational strategy of sequence and structural analysis predicts the existence of a functional eicosanoid pathway in Drosophila melanogaster.
Immune suppressive extracellular vesicle proteins of Leptopilina heterotoma are encoded in the wasp genome.
Spaceflight and simulated microgravity conditions increase virulence of Serratia marcescens in the Drosophila melanogaster infection model.
A parasitoid wasp of Drosophila employs preemptive and reactive strategies to deplete its host's blood cells
In Silico Analysis of a Drosophila Parasitoid Venom Peptide Reveals Prevalence of the Cation–Polar–Cation Clip Motif in Knottin Proteins
Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids.
Drosophila parasitoids go to space: Unexpected effects of spaceflight on hosts and their parasitoids
Simultaneous exposure of cultured human lymphoblastic cells to simulated microgravity and radiation increases chromosome aberrations
Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.
Physical Forces Modulate Oxidative Status and Stress Defense Meditated Metabolic Adaptation of Yeast Colonies: Spaceflight and Microgravity Simulations
Effects of space flight on mouse liver versus kidney: Gene pathway analyses.
Yeast in Space
Endocrine Effects of Space Flight
Role of shear stress on renal proximal tubular cells for nephrotoxicity assays
Bone hemodynamic responses to changes in external pressure.
Back pain in space and post-flight spine injury: Mechanisms and countermeasure development
Fifteen days of microgravity causes growth in calvaria of mice
Altered disc compression in children with idiopathic low back pain: an upright magnetic resonance imaging backpack study
Spaceflight-induced bone loss alters failure mode and reduces bending strength in murine spinal segments.
Spaceflight-associated vascular remodeling and gene expression in mouse calvaria.
Exposure of Mycobacterium marinum to low-shear modeled microgravity: Effect on growth, the transcriptome and survival under stress.
Effects of mechanostimulation on gravitropism and signal persistence in flax roots.
Oxygen dependency of germinating Brassica seeds.
Desiccation mitigates heat stress in the resurrection fern, Pleopeltis polypodioides
Transcription profile of auxin related genes during positively gravitropic hypocotyl curvature of Brassica rapa.
High-gradient magnetic fields and starch metabolism: Results from a space experiment.
Lipid rafts and plant gravisensitivity.
Expression and characterization of the bacterial mechanosensitive channel MscS in Xenopus laevis oocytes
United in Diversity: Mechanosensitive Ion Channels in Plants
Expressing and Characterizing Mechanosensitive Channels in Xenopus Oocytes
The ongoing search for the molecular basis of plant osmosensing
Plastid osmotic stress influences cell differentiation at the plant shoot apex.
Spaceflight-induced synaptic modifications within hair cells of the mammalian utricle.
Effects of angular frequency during clinorotation on mesenchymal stem cell morphology and migration
The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization.
Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer.
To Infinity and Beyond! Human spaceflight and life science.
Hyperoxia inhibits T cell activation in mice
Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules
n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial
Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates
Spaceflight alters expression of microRNA during T-cell activation
Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines.
From cellular mechanotransduction to biologically inspired engineering: 2009 Pritzker Award Lecture, BMES Annual Meeting October 10, 2009.
Crewmember microbiome may influence microbial composition of ISS habitable surfaces
Sierra Nevada sweep: Metagenomic measurements of bioaerosols vertically distributed across the troposphere.
Draft Genome Sequences of Fungi Isolated from the International Space Station during the Microbial Tracking-2 Experiment
Microbial tracking-2, a metagenomics analysis of bacteria and fungi onboard the International Space Station.
Detection of Target Genes for Drug Repurposing to Treat Skeletal Muscle Atrophy in Mice Flown in Spaceflight
Release of CD36-associated cell-free mitochondrial DNA and RNA as a hallmark of space environment response
Increasing the number of unloading/reambulation cycles does not adversely impac body composition and lumbar bone mineral density but reduces tissue sensitivity
Bone shaft bending strength index is unaffected by exercise and unloading in mice
Focal enhancement of the skeleton to exercise correlates to mesenchymal stem cell responsivity rather than peak external forces.
Cytoskeletal configuration modulates mechanically induced changes in mesenchymal stem cell osteogenesis, morphology, and stiffness.
Genetic and tissue level muscle-bone interactions during unloading and reambulation.
Osteocyte apoptosis caused by hindlimb unloading is required to trigger osteocyte RANKL production and subsequent resorption of cortical and trabecular bone in mice femurs.
Differential Single Cell Responses of Embryonic Stem Cells Versus Embryoid Bodies to Gravity Mechanostimulation
Macrophages inhibit Aspergillus fumigatus germination and neutrophil-mediated fungal killing.
Contributions of spore secondary metabolites to UV-C protection and virulence vary in different Aspergillus fumigatus strains
Regulation of hemocytes in Drosophila requires dappled cytochrome b5.
A novel phototropic response to red light is revealed in microgravity.
Plant cell proliferation and growth are altered by microgravity conditions in spaceflight.
Phototropism of Arabidopsis thaliana in microgravity and fractional gravity on the International Space Station.
Light and gravity signals synergize in modulating plant development
A novel blue-light phototropic response is revealed in roots of Arabidopsis thaliana in microgravity.
Comparative transcriptomics indicate changes in cell wall organization and stress response in seedlings during spaceflight
RNAseq analysis of the response of Arabidopsis thaliana to fractional gravity under blue-light stimulation during spaceflight
Comparison of Microgravity Analogs to Spaceflight in Studies of Plant Growth and Development
The importance of Earth reference controls in spaceflight-omics research: Characterization of nucleolin mutants from the Seedling Growth experiments
Conducting plant experiments in space and on the Moon
Red light enhances plant adaptation to spaceflight and Mars g-levels.
EUK-134 ameliorates nNOSµ translocation and skeletal muscle fiber atrophy during short-term mechanical unloading.
MnSOD Overexpression Reduces Fibrosis and Pro-Apoptotic Signaling in the Aging Mouse Heart
Lifelong wheel running exercise and mild caloric restriction attenuate nuclear EndoG in the aging plantaris muscle.
Age-related alterations in the sarcolemmal environment are attenuated by lifelong caloric restriction and voluntary exercise.
The impact of SRT2104 on skeletal muscle mitochondrial function, redox biology, and loss of muscle mass in hindlimb unloaded rats.
Bioreactor development for skeletal muscle hypertrophy and atrophy by manipulating uniaxial cyclic strain: Proof of concept.
Genomic and phenotypic characterization of Burkholderia isolates from the potable water system of the International Space Station
CAMDLES: CFD-DEM Simulation of Microbial Communities in Spaceflight and Artificial Microgravity
Hardware validation of the Advanced Plant Habitat on ISS: Canopy photosynthesis in reduced gravity.
Trimeric structure of (+)-pinoresinol-forming dirigent protein at 1.95 A resolution with three isolated active sites.
Reduced Arogenate Dehydratase Expression: Ramifications for Photosynthesis and Metabolism
New insights into lignification via network and multi-omics analyses of arogenate dehydratase knock-out mutants in Arabidopsis thaliana
Functional consequences of radiation-induced oxidative stress in cultured neural stem cells and the brain exposed to charged particle irradiation
Exploration of space to achieve scientific breakthroughs
Network Analysis of Gene Transcriptions of Arabidopsis thaliana in Spaceflight Microgravity.
Detection of Genes in Arabidopsis thaliana L. Responding to DNA Damage from Radiation and Other Stressors in Spaceflight
The Effect of spaceflight on mouse olfactory bulb volume, neurogenesis, and cell death indicates the protective effect of novel environment.
Effects of low-dose rate γ-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart
Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.
Mice Exposed to Combined Chronic Low-Dose Irradiation and Modeled Microgravity Develop Long-Term Neurological Sequelae.
Spaceflight influences gene expression, photoreceptor integrity, and oxidative stress-related damage in the murine retina.
Evaluating ocular response in the retina and optic nerve head after single and fractionated high-energy protons
Characterization of gene expression profiles in the mouse brain after 35 days of spaceflight mission.
A multi-omics longitudinal study of the murine retinal response to chronic low-dose irradiation and simulated microgravity.
Evidence of spaceflight-induced adverse effects on photoreceptors and retinal function in the mouse eye.
Effects of spaceflight on the brain
Routine omics collection is a golden opportunity for European human research in space and analog environments.
Spatial omics technologies at multimodal and single cell/subcellular level.
Genomic characterization and radiation tolerance of Naganishia kalamii sp. nov. and Cystobasidium onofrii sp. nov. from Mars 2020 mission assembly facilities.
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight
Inspiration4 data access through the NASA Open Science Data Repository
Molecular and physiologic changes in the SpaceX Inspiration4 civilian crew
Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing
Spatial multi-omics of human skin reveals KRAS and inflammatory responses to spaceflight
Longitudinal multi-omics analysis of host microbiome architecture and immune responses during short-term spaceflight
Spatiotemporal expression and control of haemoglobin in space
Single-cell multi-ome and immune profiles of the Inspiration4 crew reveal conserved, cell-type, and sex-specific responses to spaceflight
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
Astronaut omics and the impact of space on the human body at scale
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.
Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction
Spaceflight induces changes in gene expression profiles linked to insulin and estrogen
Protective alleles and precision healthcare in crewed spaceflight
To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants
Growth chambers on the International Space Station for large plants
Microbiological and nutritional analysis of lettuce crops grown on the International Space Station
Natural variation in the expression of ORGANIC CATION TRANSPORTER 1 affects root length responses to cadaverine in Arabidopsis.
Auxin: Shape matters.
Gravity signaling in flowering plant roots
Cadaverine regulates biotin synthesis to modulate primary root growth in Arabidopsis
Low-speed clinorotation of Brachypodium distachyon and Arabidopsis thaliana seedlings triggers root tip curvatures that are reminiscent of gravitropism.
New device for high-throughput viability screening of flow biofilms
Sigma S-dependent antioxidant defense protects stationary-phase Escherichia coli against the bactericidal antibiotic gentamicin
Plasma membrane disruption (PMD) formation and repair in mechanosensitive tissues
Microgravity alters the expression of salivary proteins
Salivary Gland Protein Expression after Bion-M1 and Space Shuttle STS-135 Missions
Response of the mouse sublingual gland to spaceflight.
Effects of spaceflight on the mouse submandibular gland
Reactivation of Latent Epstein-Barr Virus: A Comparison after Exposure to Gamma, Proton, Carbon, and Iron Radiation
The influence of spaceflight on the astronaut salivary microbiome and the search for a microbiome biomarker for viral reactivation
The cyclic nucleotide-gated channel CNGC14 regulates root gravitropism in Arabidopsis thaliana.
Telomere length assessments of muscle stem cells in rodent and human skeletal muscle sections
Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening
Piezo1 regulates the regenerative capacity of skeletal muscles via orchestration of stem cell morphological states.
Impacts of radiation exposure, hindlimb unloading, and recovery on murine skeletal muscle cell telomere length.
Ethylene-induced flavonol accumulation in guard cells suppresses reactive oxygen species and modulates stomatal aperture
Transcriptional and Hormonal Regulation of Gravitropism of Woody Stems in Populus.
Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis
A conditional mutation in SCD1 reveals linkage between PIN protein trafficking, auxin transport, gravitropism, and lateral root initiation.
A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection.
Changes in nuclear shape and gene expression in response to simulated microgravity are LINC complex-dependent.
Growth of Carnobacterium spp. from permafrost under low pressure, temperature, and anoxic atmosphere has implications for Earth microbes on Mars
Complete Genome Sequence of Carnobacterium gilichinskyi Strain WN1359T (DSM 27470T)
Exposure of Bacillus subtilis to low pressure (5 kilopascals) induces several global regulons, including those involved in the SigB-mediated general stress response
Resistance of Bacillus subtilis Spore DNA to Lethal Ionizing Radiation Damage Relies Primarily on Spore Core Components and DNA Repair, with Minor Effects of Oxygen Radical Detoxification
Cultivation of Staphylococcus epidermidis in the human spaceflight environment leads to alterations in the frequency and spectrum of spontaneous rifampicin-resistance mutations in the rpoB gene
Experimental Evolution of Bacillus subtilis
Cultivation in space flight produces minimal alterations in the susceptibility of Bacillus subtilis cells to 72 different antibiotics and growth-inhibiting compounds
Alterations in the Spectrum of Spontaneous Rifampicin-Resistance Mutations in the Bacillus subtilis rpoB Gene after Cultivation in the Human Spaceflight Environment
Mechanotransduction in Prokaryotes: A Possible Mechanism of Spaceflight Adaptation
Environmental dependence of competitive fitness in rifampin-resistant rpoB mutants of Bacillus subtilis.
Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells.
Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions.
Induction of attachment-independent biofilm formation and repression of Hfq expression by low-fluid-shear culture of Staphylococcus aureus
Characterization of the Salmonella enterica serovar Typhimurium ydcI gene which encodes a conserved DNA binding protein required for full acid stress resistance.
Evaluation of microorganisms cultured from injured and repressed tissue regeneration sites in endangered giant aquatic Ozark Hellbender salamanders.
Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen.
New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli
Lack of norovirus replication and histo-blood group antigen expression in 3-dimensional intestinal epithelial cells
Conservation of the low-shear modeled microgravity response in Enterobacteriaceae and analysis of the trp genes in this response.
Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa.
Effects of Sex and Gender on Adaptation to Space: Immune System
Recellularization of decellularized lung scaffolds is enhanced by dynamic suspension culture.
Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns.
Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age.
Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium
Rapid phenotypic response of LSMMG-'primed' Candida albicans.
Spaceflight enhances cell aggregation and random budding in Candida albicans.
Growth and antifungal resistance of the pathogenic yeast, Candida albicans, in the microgravity environment of the International Space Station: An aggregate of multiple flight experiences.
NASA GeneLab RNA-Seq Consensus Pipeline: Standardized Processing of Short-Read RNA-Seq Data
Challenges and considerations for single-cell and spatially resolved transcriptomics sample collection during spaceflight.
Direct RNA sequencing of astronaut blood reveals spaceflight-associated m6A increases and hematopoietic transcriptional responses
Collection of biospecimens from the inspiration4 mission establishes the standards for the space omics and medical atlas (SOMA)
Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics.
Multiparameter behavioral analyses provide insights to mechanisms of cyanide resistance in Caenorhabditis elegans.
Growth performance and root transcriptome remodeling of Arabidopsis in response to Mars-like levels of magnesium sulfate.
The 14-3-3 proteins of Arabidopsis regulate root growth and chloroplast development as components of the photosensory system.
14-3-3 phosphoprotein interaction networks - does isoform diversity present functional interaction specification?
Plant growth strategies are remodeled by spaceflight
Spaceflight transcriptomes: unique responses to a novel environment.
Fundamental plant biology enabled by the space shuttle.
Organ-specific remodeling of the Arabidopsis transcriptome in response to spaceflight.
A method for preparing spaceflight RNAlater-fixed Arabidopsis thaliana (Brassicaceae) tissue for scanning electron microscopy.
ARG1 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight
A Member of the CONSTANS-Like Protein Family is a Putative Regulator of ROS Homeostasis and Spaceflight Physiological Adaptation
HSFA2 Functions in the Physiological Adaptation of Undifferentiated Plant Cells to Spaceflight.
Neutrophil to Lymphocyte ratio: A biomarker to monitor the immune status of astronauts.
Beyond low-Earth orbit: Characterizing immune and microRNA differentials following simulated deep spaceflight conditions in mice.
Immunological and hematological outcomes following protracted low dose/low dose rate ionizing radiation and simulated microgravity
Epigenomic regulators elongator complex subunit 2 and methyltransferase 1 differentially condition the spaceflight response in Arabidopsis
Plants grown in Apollo lunar regolith present stress-associated transcriptomes that inform prospects for lunar exploration
Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster.
Utilizing the KSC fixation tube to conduct human-tended plant biology experiments on a suborbital spaceflight
Changes in Mouse Thymus and Spleen after Return from the STS-135 Mission in Space
Post-Spaceflight (STS-135) Mouse Splenocytes Demonstrate Altered Activation Properties and Surface Molecule Expression.
Changes in the distribution and function of leukocytes after whole-body iron ion irradiation.
Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism?
Spaceflight Activates Autophagy Programs and the Proteasome in Mouse Liver
Vive la radiorésistance!: Converging research in radiobiology and biogerontology to enhance human radioresistance for deep space exploration and colonization.
Proteomic analysis of mouse brain subjected to spaceflight.
Transcriptomic effects on the mouse heart following 30 days on the International Space Station.
Spaceflight-induced gene expression profiles in the mouse brain are attenuated by treatment with the antioxidant BuOE
Basal signaling regulates plant growth and development
Phosphoinositide-signaling is one component of a robust plant defense response
Uncovering transcriptional responses to fractional gravity in Arabidopsis roots
Conserved plant transcriptional responses to microgravity from two consecutive spaceflight experiments.
RNAseq analysis of rodent spaceflight experiments is confounded by sample collection techniques
Functional changes in the snail statocyst system elicited by microgravity
Simulated microgravity impairs human NK [natural killer] cell cytotoxic activity against space radiation-relevant leukemic cells
Multi-analyte biochip (MAB) based on all-solid-state ion-selective electrodes (ASSISE) for physiological research
Lab-on-a-chip approaches for space-biology research.
Plant chemical genomics: gravity sensing and response.
The interaction of vortical flows with red cells in venous valve mimics.
Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight
Investigation of simulated microgravity effects on Streptococcus mutans physiology and global gene expression.
Altered quorum sensing and physiology of Staphylococcus aureus during spaceflight detected by multi-omics data analysis
Homotypic vacuole fusion requires VTI11 and is regulated by phosphoinositides
REGULATOR OF BULB BIOGENESIS1 (RBB1) Is Involved in Vacuole Bulb Formation in Arabidopsis.
Phosphoinositides control the localization of HOPS subunit VPS41, which together with VPS33 mediates vacuole fusion in plants.
Microgravity enhances the phenotype of Arabidopsis zigzag-1 and reduces the Wortmannin-induced vacuole fusion in root cells.
Hypergravity disruption of homeorhetic adaptations to lactation in rat dams include changes in circadian clocks
Intrauterine exposure to maternal stress alters Bdnf IV DNA methylation and telomere length in the brain of adult rat offspring.
Influence of gonadectomy on muscle health in micro- and partial-gravity environments in rats.
Sex differences in muscle health in simulated micro- and partial-gravity environments in rats.
Brassinazole resistant 1 (BZR1)-dependent brassinosteroid signalling pathway leads to ectopic activation of quiescent cell division and suppresses columella stem cell differentiation
Proteomic study of microsomal proteins reveals a key role for Arabidopsis Annexin 1 in mediating heat stress-induced increase in intracellular calcium levels.
Apyrase inhibitors enhance the ability of diverse fungicides to inhibit the growth of different plant-pathogenic fungi
ANN1 and ANN2 Function in Post-Phloem Sugar Transport in Root Tips to Affect Primary Root Growth
Mitochondria-targeted human catalase in the mouse longevity MCAT model mitigates head-tilt bedrest-induced neuro-inflammation in the hippocampus.
Structural and functional properties of bone are compromised in amyotrophic lateral sclerosis mice.
Longitudinal time course of muscle impairments during partial weight-bearing in rats
The partial weight-bearing rat model using a pelvic harness does not impact stress or hindlimb blood flow.
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats.
Approaching Gravity as a Continuum Using the Rat Partial Weight-Bearing Model
Hindlimb suspension in Wistar rats: Sex-based differences in muscle response
Adaptation to full weight-bearing following disuse in rats: The impact of biological sex on musculoskeletal recovery
Effects of liquid cultivation on gene expression and phenotype of C. elegans.
Transcriptomic Signature of the Simulated Microgravity Response in Caenorhabditis elegans and Comparison to Spaceflight Experiments.
Enabling clonal analyses of yeast in outer space by encapsulation and desiccation in hollow microparticles.
Caenorhabditis elegans in microgravity: An omics perspective
Dried plum diet protects from bone loss caused by ionizing radiation
Dietary countermeasure mitigates simulated spaceflight-induced osteopenia in mice
Simulated microgravity alters gene regulation linked to immunity and cardiovascular disease
Autophagy and its consequences for platelet biology
A new role of NAP1L1 in megakaryocytes and human platelets
Evaluation of rodent spaceflight in the NASA animal enclosure module for an extended operational period (up to 35 days)
Morphology of Penicillium rubens Biofilms Formed in Space
Explainable machine learning identifies multi-omics signatures of muscle response to spaceflight in mice
Microbial adaptation to spaceflight is correlated with bacteriophage-encoded functions
Influence of the spaceflight environment on macrophage lineages
MARSBOx: Fungal and bacterial endurance from a balloon-flown analog mission in the stratosphere
In situ linkage of fungal and bacterial proliferation to microbiologically influenced corrosion in B20 biodiesel storage tanks.
Identification of metagenome-assembled genomes containing antimicrobial resistance genes, isolated from an advanced water treatment facility.
Nature of pre-earthquake phenomena and their effects on living organisms
The rapid diagnosis and effective inhibition of coronavirus using spike antibody attached gold nanoparticles
Blocking SARS-CoV-2 Delta variant (B.1.617.2) spike protein receptor-binding domain binding with the ACE2 receptor of the host cell and inhibiting virus infections using human host defense peptide-conjugated graphene quantum dots.
Safety and pharmacokinetics of intranasally administered heparin
Inhibition of SARS-CoV-2 wild-type (Wuhan-Hu-1) and Delta (B.1.617.2) strains by marine sulfated glycans.
Inhibition of Cytomegalovirus by Pentacta pygmaea Fucosylated Chondroitin Sulfate Depends on Its Molecular Weight
Effect of simulated cosmic radiation on cytomegalovirus reactivation and lytic replication
A Tissue Retrieval and Postharvest Processing Regimen for Rodent Reproductive Tissues Compatible with Long-Term Storage on the International Space Station and Postflight Biospecimen Sharing Program
Effects of sex and gender on adaptations to space: reproductive health
Effects of spaceflight on the muscles of the murine shoulder.
Multiscale effects of spaceflight on murine tendon and bone
Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight.
Failure to Generate Bone Marrow Adipocytes Does Not Protect Mice from Ovariectomy-Induced Osteopenia
Acute exposure to high dose gamma-radiation results in transient activation of bone lining cells
Morbid obesity attenuates the skeletal abnormalities associated with leptin deficiency in mice
Hypothalamic leptin gene therapy reduces body weight without accelerating age-related bone loss
Hypothalamic Leptin Gene Therapy Reduces Bone Marrow Adiposity in ob/ob Mice Fed Regular and High-Fat Diets.
Room temperature housing results in premature cancellous bone loss in growing female mice: implications for the mouse as a preclinical model for age-related bone loss.
Spaceflight-induced vertebral bone loss in ovariectomized rats is associated with increased bone marrow adiposity and no change in bone formation
Role of oestrogen receptor signaling in skeletal response to leptin in female ob/ob mice.
Effects of hypothalamic leptin gene therapy on osteopetrosis in leptin-deficient mice.
Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism.
Bone Marrow Adipose Tissue Deficiency Increases Disuse-Induced Bone Loss in Male Mice
Metabolic Coupling Between Bone Marrow Adipose Tissue and Hematopoiesis
Maintenance of near normal bone mass and architecture in lethally irradiated female mice following adoptive transfer with as few as 750 purified hematopoietic stem cells.
Effect of leptin deficiency on the skeletal response to hindlimb unloading in adult male mice.
Thermoneutral housing attenuates premature cancellous bone loss in male C57BL/6J mice
Effects of Spaceflight on Cancellous and Cortical Bone in Proximal Femur in Growing Rats
Evidence for increased thermogenesis in female C57BL/6J mice housed aboard the international space station
Leptin and environmental temperature as determinants of bone marrow adiposity in female mice
Small changes in thermoregulation influence cancellous bone turnover balance in distal femur metaphysis in growing female mice
Bone Marrow Adipose Tissue Is Not Required for Reconstitution of the Immune System Following Irradiation in Male Mice
Simulated Microgravity Promotes Horizontal Gene Transfer of Antimicrobial Resistance Genes between Bacterial Genera in the Absence of Antibiotic Selective Pressure
Understanding the Complexities and Changes of the Astronaut Microbiome for Successful Long-Duration Space Missions
Toward sustainable space exploration: a roadmap for harnessing the power of microorganisms.
Roll maneuvers are essential for active reorientation of Caenorhabditis elegans in 3D media
Microfluidic Device for Studying Nematodes
NemaFlex: A microfluidics-based technology for standardized measurement of muscular strength of C. elegans.
Swim exercise in Caenorhabditis elegans extends neuromuscular and gut healthspan, enhances learning ability, and protects against neurodegeneration
Molecular muscle experiment: Hardware and operational lessons for future astrobiology space experiments
Tart Cherry Increases Lifespan in Caenorhabditis elegans by Altering Metabolic Signaling Pathways
A region of UNC-89 (obscurin) lying between two protein kinase domains is a highly elastic spring required for proper sarcomere organization
NemaLife chip: a micropillar-based microfluidic culture device optimized for aging studies in crawling C. elegans
Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans
Microfluidics-integrated spaceflight hardware for measuring muscle strength of Caenorhabditis elegans on the International Space Station.
A Compact Imaging Platform for Conducting C. elegans Phenotypic Assays on Earth and in Spaceflight.
Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans.
Bisphosphonates attenuate age-related muscle decline in Caenorhabditis elegans.
Spaceflight Induces Strength Decline in Caenorhabditis elegans
Metabolic model predictions enable targeted microbiome manipulation through precision prebiotics.
Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology.
Identification and characterization of a skin microbiome on Caenorhabditis elegans suggests environmental microbes confer cuticle protection
Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function
New perspectives on viable microbial communities in low-biomass cleanroom environments
Microbial existence in controlled habitats and their resistance to space conditions
Microbiomes of the dust particles collected from the International Space Station and Spacecraft assembly facilities
Draft genome sequences of two Aspergillus fumigatus strains, isolated from the International Space Station
Characterization of Aspergillus fumigatus isolates from air and surfaces of the International Space Station.
Draft genome sequences of biosafety level 2 opportunistic pathogens isolated from the environmental surfaces of the International Space Station.
Draft Genome Sequences of Several Fungal Strains Selected for Exposure to Microgravity at the International Space Station.
Human presence impacts fungal diversity of inflated lunar/Mars analog habitat.
Whole metagenome profiles of particulates collected from the International Space Station
Microbial Characteristics of ISS Environmental Surfaces
Draft Genome Sequences from a Novel Clade of Bacillus cereus Sensu Lato Strains, Isolated from the International Space Station.
Draft Genome Sequences of Acinetobacter and Bacillus Strains Isolated from Spacecraft-Associated Surfaces
KatharoSeq enables high-throughput microbiome analysis from low-biomass samples
Draft genome sequence of a clinical isolate of Fusarium fujikuroi isolated from a male patient with acute myeloid leukemia.
Draft Genome Sequence of Solibacillus kalamii, Isolated from an Air Filter Aboard the International Space Station
Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces
Draft genome sequences of two Fusarium oxysporum isolates cultured from infected Zinnia hybrida plants grown on the International Space Station.
Characterization of Aspergillus niger Isolated from the International Space Station
Multi-drug resistant Enterobacter bugandensis species isolated from the International Space Station and comparative genomic analyses with human pathogenic strains
Succession and persistence of microbial communities and antimicrobial resistance genes associated with International Space Station environmental surfaces
International Space Station conditions alter genomics, proteomics, and metabolomics in Aspergillus nidulans.
Proteomic characterization of Aspergillus fumigatus isolated from air and surfaces of the International Space Station.
Genomic Characterization and Virulence Potential of Two Fusarium oxysporum Isolates Cultured from the International Space Station
Characterization of the total and viable bacterial and fungal communities associated with the International Space Station surfaces.
Proteomic and Metabolomic Characteristics of Extremophilic Fungi Under Simulated Mars Conditions.
MetaMiner: A Scalable Peptidogenomics Approach for Discovery of Ribosomal Peptide Natural Products with Blind Modifications from Microbial Communities
Draft Genome Sequences of Sphingomonas Species Associated with the International Space Station
Draft Genome Sequences of Tremellomycetes Strains Isolated from the International Space Station
Draft Genome Sequences of Rhodotorula mucilaginosa Strains Isolated from the International Space Station
Draft Genome Sequences of Enterobacteriales Strains Isolated from the International Space Station
Draft Genome Sequences of Lactobacillales Isolated from the International Space Station
Draft Genome Sequences of Klebsiella Species Isolated from the International Space Station
Draft Genome Sequences of Bacillaceae Strains Isolated from the International Space Station.
Assessing the risk of transfer of microorganisms at the International Space Station due to cargo delivery by commercial resupply vehicles
Methylobacterium ajmalii sp. nov., isolated from the International Space Station
Draft Genome Sequences of Aspergillus and Penicillium Species Isolated from the International Space Station and Crew Resupply Vehicle Capsule
Advances in Space Microbiology
Effects of simulated microgravity on the proteome and secretome of the polyextremotolerant black fungus Knufia chersonesos.
Draft Genome Sequences of Various Bacterial Phyla Isolated from the International Space Station
Evaluating the lettuce metatranscriptome with MinION sequencing for future spaceflight food production applications
Investigation of Spaceflight Induced Changes to Astronaut Microbiomes
Genomic Characterization of Potential Plant Growth-Promoting Features of Sphingomonas Strains Isolated from the International Space Station
Genomic Characterization of the Titan-like Cell Producing Naganishia tulchinskyi, the First Novel Eukaryote Isolated from the International Space Station
Metabolic modeling of the International Space Station microbiome reveals key microbial interactions.
Microbial Burden Estimation of Food Items, Built Environments, and the International Space Station Using Film Media
Multidrug-resistant Acinetobacter pittii is adapting to and exhibiting potential succession aboard the International Space Station.
Characterization of metagenome-assembled genomes from the International Space Station.
Comparative genomic analysis of Cohnella hashimotonis sp. nov. isolated from the International Space Station
Genomic analysis reveals the presence of emerging pathogenic Klebsiella lineages aboard the International Space Station
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes
Genomic, functional, and metabolic enhancements in multidrug-resistant Enterobacter bugandensis facilitating its persistence and succession in the International Space Station
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes
Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis
Spatial regulation of a common precursor from two distinct genes generates metabolite diversity
Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018).
Cortical thinning and structural bone changes in non-human primates after single-fraction whole-chest irradiation.
Knee and Hip Joint Cartilage Damage from Combined Spaceflight Hazards of Low-Dose Radiation Less than 1 Gy and Prolonged Hindlimb Unloading.
The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes
Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents
αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading
Prolonged exposure to particulate chromate inhibits RAD51 nuclear import mediator proteins.
Transcriptomics, NF-κB Pathway, and Their Potential Spaceflight-Related Health Consequences.
Interplay of space radiation and microgravity in DNA damage and DNA damage response.
Synergistic Effects of Weightlessness, Isoproterenol, and Radiation on DNA Damage Response and Cytokine Production in Immune Cells
Transcriptome and proteome responses in RNAlater preserved tissue of Arabidopsis thaliana.
Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses.
Mitigation and use of biofilms in space for the benefit of human space exploration
Toward sustainable space exploration: A roadmap for harnessing the power of microorganisms.
Longitudinal characterization of multispecies microbial populations recovered from spaceflight potable water
Designing a Novel Monitoring Approach for the Effects of Space Travel on Astronauts’ Health
Draft genome sequence of Sphingomonas paucimobilis strain Sph5, isolated from tap water filtration membrane
Overexpression of CupB5 activates alginate overproduction in Pseudomonas aeruginosa by a novel AlgW-dependent mechanism
Burn injury-associated MHCII(+) immune cell accumulation around lymphatic vessels of the mesentery and increased lymphatic endothelial permeability are blocked by doxycycline treatment.
CubeSats for microbiology and astrobiology research
In situ resource utilisation: The potential for space biomining
The smallest space miners: Principles of space biomining
Simulated micro-, lunar, and Martian gravities on Earth—effects on Escherichia coli growth, phenotype, and sensitivity to antibiotics.
Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces.
Competitive Growth Assay of Mutagenized Chlamydomonas reinhardtii Compatible With the International Space Station Veggie Plant Growth Chamber.
Spatial Characterization of Microbial Communities on Multi-Species Leafy Greens Grown Simultaneously in the Vegetable Production Systems on the International Space Station
Response of Arabidopsis thaliana and Mizuna mustard seeds to simulated space radiation exposures.
Editorial: Revisiting the limits of plant life - plant adaptations to extreme terrestrial environments relating to astrobiology and space biology.
Metagenomic interrogation of urban Superfund site reveals antimicrobial resistance reservoir and bioremediation potential.
In situ monitoring of barrier function on-chip via automated, non-invasive luminescence sensing.
37-day microgravity exposure in 16-week female C57BL/6J mice is associated with bone loss specific to weight-bearing skeletal sites.
Effects of Space Flight on Inflammasome Activation in the Brain of Mice.
Immunization induces inflammation in the mouse heart during spaceflight.
Analyzing the relationship between gene expression and phenotype in space-flown mice using a causal inference machine learning ensemble.
Sex-specific cardiovascular adaptations to simulated microgravity in Sprague-Dawley rats
NASA open science data repository: Open science for life in space.
Artificial gravity attenuates the transcriptomic response to spaceflight in the optic nerve and retina
Effect of simulated cosmic radiation on cytomegalovirus reactivation and lytic replication.
Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function.
To boldly go where no microRNAs have gone before: Spaceflight impact on risk for small-for-gestational-age infants.
Adaptation to space conditions of novel bacterial species isolated from the International Space Station revealed by functional gene annotations and comparative genome analysis.
Celebrating 30 years of access to NASA space life sciences data.
Predicting how varying moisture conditions impact the microbiome of dust collected from the International Space Station.
Spaceflight alters host-gut microbiota interactions.
Discoveries from human stem cell research in space that are relevant to advancing cellular therapies on Earth.
Simulated microgravity impairs human NK [natural killer] cell cytotoxic activity against space radiation-relevant leukemic cells.
Simulated microgravity alters gene regulation linked to immunity and cardiovascular disease.
Spaceflight increases sarcoplasmic reticulum Ca2+ leak and this cannot be counteracted with BuOE treatment